庆大霉素和奈替米星的肾毒性比较：与尿酶活性的功能和形态学相关性
Comparative nephrotoxicity of gentamicin and netilmicin: functional and morphological correlations with urinary enzyme activities.
作者信息
Adelman R D, Conzelman G, Spangler W, Ishizaki G
出版信息
Curr Probl Clin Biochem. 1979(9):166-82.
PMID:446071
Abstract
An increase in urinary enzyme activities reflected biopsy confirmed aminoglycoside nephrotoxicity (proximal tubular injury) before changes in blood urea nitrogen, serum creatinine, urinary osmolality and urinary protein excretion. Netilmicin, a semisynthetic derivative of gentamicin, was less nephrotoxic than gentamicin.
摘要
尿酶活性增加反映活检证实的氨基糖苷类肾毒性（近端肾小管损伤），早于血尿素氮、血清肌酐、尿渗透压和尿蛋白排泄的变化。奈替米星，庆大霉素的半合成衍生物，肾毒性比庆大霉素小。
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Furosemide enhancement of experimental gentamicin nephrotoxicity: comparison of functional and morphological changes with activities of urinary enzymes.
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The nephrotoxic potential of netilmicin as determined in a rat model.在大鼠模型中测定的奈替米星的肾毒性潜力。
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Enzymuria in aminoglycoside-induced kidney damage. Comparative study of gentamicin, amikacin, sisomicin and netilmicin.氨基糖苷类药物所致肾损害中的酶尿。庆大霉素、阿米卡星、西索米星和奈替米星的比较研究。
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Netilmicin and tobramycin. Comparison of nephrotoxicity in dogs.奈替米星和妥布霉素。犬肾毒性的比较。
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The effect of netilmicin and other aminoglycosides on renal function. A survey of the literature on the nephrotoxicity of netilmicin.奈替米星及其他氨基糖苷类药物对肾功能的影响。关于奈替米星肾毒性的文献综述。
Scand J Infect Dis Suppl. 1980;Suppl 23:96-102.
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[Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects. (1). Nephrotoxicity of gentamicin and mercuric chloride].[氨基糖苷类抗生素的肾毒性及其防护研究。（1）。庆大霉素与氯化汞的肾毒性]
Nihon Yakurigaku Zasshi. 1984 Nov;84(5):453-62.
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Preclinical toxicologic studies of netilmicin.
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