庆大霉素和奈替米星的肾毒性比较：与尿酶活性的功能和形态学相关性
Comparative nephrotoxicity of gentamicin and netilmicin: functional and morphological correlations with urinary enzyme activities.
作者信息
Adelman R D, Conzelman G, Spangler W, Ishizaki G
出版信息
Curr Probl Clin Biochem. 1979(9):166-82.
PMID:446071
Abstract
An increase in urinary enzyme activities reflected biopsy confirmed aminoglycoside nephrotoxicity (proximal tubular injury) before changes in blood urea nitrogen, serum creatinine, urinary osmolality and urinary protein excretion. Netilmicin, a semisynthetic derivative of gentamicin, was less nephrotoxic than gentamicin.
摘要
尿酶活性增加反映活检证实的氨基糖苷类肾毒性（近端肾小管损伤），早于血尿素氮、血清肌酐、尿渗透压和尿蛋白排泄的变化。奈替米星，庆大霉素的半合成衍生物，肾毒性比庆大霉素小。
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