强效尿促凝血剂及其与肾脏疾病的关系。
The powerful urinary procoagulant and its relation to renal diseases.
作者信息
von Kaulla K N, von Kaulla E
出版信息
Curr Probl Clin Biochem. 1979(9):342-55.
Human urine and urine of various animals contains a powerful procoagulant which converts prothrombin in presence of factors V, VII, X, and phospholipids or thrombocytes into thrombin. In human beings its content of the urine is markedly reduced or totally absent in kidney diseases, but normal in hemophilic patients. Only 0.2 ml urine are required for its assessment. In experimental kidney diseases in rabbits and rats there is an inverse relationship between procoagulant and protein excretion. In the test tube 1 part of urine corrects the clotting of 5-10 parts of hemophilic plasma, even in the presence of very strong coagulation inhibitors.
人类尿液及各种动物的尿液中含有一种强大的促凝血剂，该促凝血剂在因子V、VII、X以及磷脂或血小板存在的情况下，可将凝血酶原转化为凝血酶。在人类中，其在尿液中的含量在肾脏疾病时会显著降低或完全缺失，但在血友病患者中则正常。评估其含量仅需0.2毫升尿液。在兔和大鼠的实验性肾脏疾病中，促凝血剂与蛋白质排泄之间存在反比关系。在试管中，即使存在非常强的凝血抑制剂，1份尿液也能纠正5至10份血友病患者血浆的凝血。
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