Ito A
Jpn Heart J. 1974 Nov;15(6):593-609. doi: 10.1536/ihj.15.593.
The propagation process of the atrial excitation was investigated during ectopic atrial rhythms evoked by electrical pacing through stimulation at several sites in 35 isolated rabbit atria using intracellular microelectrodes. Excitation sequences was correlated with the atrial deflections in a distant bipolar electrogram representing a cranio-caudal atrial activation. The conduction velocity was faster along the crista terminalis but slower across the coronary sinus ostium than in the ordinary atrial muscle. These differences in conduction velocity resulted in the upward artial deflection on the distant bipolar electrogram in the rhythm which was produced by stimulation at the right side of the lower interatrial septum. On a function as a preferential conduction pathway in the case of left to right direction of excitation, as in left atrial rhythm. On stimulation of the postero-inferior region of the left atrium, the region around the coronary sinus ostium was the first area in the right atrium to be activated. Inversely, the impulse originating from the coronary sinus ostium wasconducted relatively fast to the postero-inferior region of the left atrium. These findings suggested that there might be a preferential conduction pathway along the coronary sinus vein or its neighbouring tissues.
利用细胞内微电极，在35个离体兔心房的多个部位进行电刺激诱发异位房性心律，研究心房兴奋的传播过程。兴奋序列与远处双极电图中的心房偏转相关，该双极电图代表头-尾方向的心房激活。沿界嵴的传导速度较快，但穿过冠状窦口的传导速度比普通心房肌慢。传导速度的这些差异导致在房间隔下部右侧刺激产生的心律中，远处双极电图上出现向上的心房偏转。在兴奋从左向右传导的情况下，如在左房心律中，其起优先传导通路的作用。刺激左房后下区域时，冠状窦口周围区域是右房中最先被激活的区域。相反，起源于冠状窦口的冲动相对快速地传导至左房后下区域。这些发现提示，可能存在一条沿冠状窦静脉或其邻近组织的优先传导通路。
