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Thiol-blocking reagents and phosphate acetyltransferase catalysis, and the assessment of protection by adsorbed molecules.硫醇阻断试剂与磷酸乙酰转移酶催化作用，以及吸附分子的保护作用评估。
Biochem J. 1974 Sep;141(3):905-7. doi: 10.1042/bj1410905.
2
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本文引用的文献

1
[PHOSPHOTRANSACETYLASE FROM CLOSTRIDIUM KLUYVERI. CULTURE OF THE BACTERIUM, ISOLATION, CRYSTALLIZATION AND PROPERTIES OF THE ENZYME].[来自克氏梭菌的磷酸转乙酰酶。细菌培养、酶的分离、结晶及性质]
Biochem Z. 1963;338:114-21.
2
Esters of methanesulfonic acid as irreversible inhibitors of acetylcholinesterase.甲磺酸酯作为乙酰胆碱酯酶的不可逆抑制剂
J Biol Chem. 1962 Oct;237:3245-9.
3
An abnormal pattern of product inhibition observed in phosphate acetyltransferase catalysis.在磷酸乙酰转移酶催化过程中观察到的产物抑制异常模式。
Biochem J. 1972 Mar;127(1):319-20. doi: 10.1042/bj1270319.
4
Kinetic studies with phosphotransacetylase. IV. Inhibition by products.
Biochim Biophys Acta. 1972 Aug 28;276(2):383-91. doi: 10.1016/0005-2744(72)90998-9.
5
Structural specificity of coenzyme A for phosphotransacetylase.
Biochim Biophys Acta. 1970 Nov 24;222(2):307-19. doi: 10.1016/0304-4165(70)90118-2.
6
Phosphotransacetylase of Escherichia coli B, purification and properties.大肠杆菌B的磷酸转乙酰酶：纯化与性质
Biochim Biophys Acta. 1969;191(3):550-8. doi: 10.1016/0005-2744(69)90348-9.
7
Kinetic studies with phosphotransacetylase. V. The mechanism of activation by univalent cations.磷酸转乙酰酶的动力学研究。V. 单价阳离子的激活机制。
Biochim Biophys Acta. 1973 Sep 15;321(1):126-42. doi: 10.1016/0005-2744(73)90066-1.
8
Alkylation studies on a reactive histidine in pig heart malate dehydrogenase.猪心苹果酸脱氢酶中活性组氨酸的烷基化研究。
Eur J Biochem. 1970 Sep;15(3):568-73. doi: 10.1111/j.1432-1033.1970.tb01042.x.

硫醇阻断试剂与磷酸乙酰转移酶催化作用，以及吸附分子的保护作用评估。

Thiol-blocking reagents and phosphate acetyltransferase catalysis, and the assessment of protection by adsorbed molecules.

作者信息

Kyrtopoulos S A, Satchell D P

出版信息

Biochem J. 1974 Sep;141(3):905-7. doi: 10.1042/bj1410905.

DOI:10.1042/bj1410905
PMID:4463969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1168195/
Abstract

Phosphate acetyltransferase (EC 2.3.1.8) is shown to be unusually sensitive to thiol-blocking reagents, and one or more thiol groups probably catalyse the surface reaction. A novel method for assessing protection by adsorbed species is described. The adsorbed substrate molecules acetyl-CoA and phosphate are found to provide substantial protection against thiol-blocking reagents.

摘要

磷酸乙酰转移酶（EC 2.3.1.8）被证明对硫醇阻断剂异常敏感，可能有一个或多个硫醇基团催化表面反应。本文描述了一种评估吸附物质保护作用的新方法。研究发现，吸附的底物分子乙酰辅酶A和磷酸盐能为硫醇阻断剂提供显著的保护作用。