两种拟合米氏积分方程方法的比较。
A comparison of two methods for fitting the integrated Michaelis-Menten equation.
作者信息
Nimmo I A, Atkins G L
出版信息
Biochem J. 1974 Sep;141(3):913-4. doi: 10.1042/bj1410913.
Abstract
The methods of Atkins & Nimmo (1973) and Fernley (1974) for fitting the integrated Michaelis-Menten equation were compared by using the same sets of simulated experimental data. The method of Fernley (1974) is to be preferred because it gives precise and unbiased estimates of the Michaelis-Menten parameters over a wide range of substrate concentrations. However, the estimates may not be symmetrically distributed, especially at low substrate concentrations.
摘要
通过使用同一组模拟实验数据，对阿特金斯和尼莫（1973年）以及弗恩利（1974年）拟合积分米氏方程的方法进行了比较。弗恩利（1974年）的方法更可取，因为在广泛的底物浓度范围内，它能给出米氏参数的精确且无偏估计。然而，这些估计可能不是对称分布的，尤其是在低底物浓度时。
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