In vivo 24-hydroxylation of 25-hydroxyvitamin D3 in enterocolectomized rats.
作者信息
Kumar R, Silva P, Epstein F H
出版信息
Endocrinology. 1979 Jun;104(6):1794-6. doi: 10.1210/endo-104-6-1794.
PMID:446398
Abstract
To determine if the renal 25-hydroxyvitamin D3 24-hydroxylase is active in addition to the intestinal 25-hydroxyvitamin D3 24-hydroxylase in vivo in the rat, radiolabeled 25-hydroxyvitamin D3 was administrated to normocalcemic, vitamin D-replete, enterocolectomized rats. Substantial amounts of 24,25-dihydroxyvitamin D3 were detected and the identity of the isolated plasma 24,25-hydroxyvitamin D3 region in these animals were confirmed by coelution on high pressure liquid chromatography and periodate cleavage. This suggests that both intestinal and renal 25-hydroxyvitamin D3 24-hydroxylases are active in vivo in the rat.
摘要
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