毒杀芬对大鼠丙酮酸和乳酸水平的影响。
Effect of toxaphene on pyruvic and lactic acid levels in the rat.
作者信息
Peakall D B
出版信息
Environ Health Perspect. 1979 Jun;30:97-8. doi: 10.1289/ehp.793097.
Rats were given a single dose of toxaphene (120 mg/kg equilavent to 1/2 LD50) and sacrificed at 1, 5, and 15 days. No alterations of levels of pyruvic or lactic acid in blood plasma were observed. In a second experiment, rats were given 2.4 mg/kg daily and sacrificed at 1, 3, and 6 months, and again no alterations of pyruvic or lactic acid levels were found. It is concluded that observed alterations of the activity of lactic acid dehydrogenase induced by toxaphene do not give rise to physiological changes in unstressed rats.
给大鼠单次注射毒杀芬（120毫克/千克，相当于1/2半数致死剂量），并在1天、5天和15天后处死。未观察到血浆中丙酮酸或乳酸水平的变化。在第二项实验中，大鼠每天注射2.4毫克/千克，并在1个月、3个月和6个月后处死，同样未发现丙酮酸或乳酸水平的变化。得出的结论是，毒杀芬诱导的乳酸脱氢酶活性的观察到的变化不会在未受应激的大鼠中引起生理变化。
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