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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Eur J Biochem. 1979 Apr;95(3):607-11. doi: 10.1111/j.1432-1033.1979.tb13001.x.

The inhibitory effect of adenosine on the glucagon-stimulated adenylate cyclase activity of liver plasma membranes, prepared from PVG/c rats, was potentiated by insulin. In the presence of EGTA, such potentiating effect of insulin was lost. 2. Calcium (10 microM) potentiated the inhibitory effects of both adenosine and insulin on the glucagon-stimulated cyclase activity. The synergestic effect of calcium + insulin required the presence of adenosine as judged from the use of adenosine deaminase. 3. Insulin had no significant inhibitory effect on the glucagon-stimulated cyclase activity of liver plasma membranes, prepared from young Wistar rats, unless both adenosine (50 microM) and calcium (10 microM) were added externally. 4. Results demonstrate an interaction of calcium and insulin at membrane level that, in the presence of adenosine, results in the inhibition of the glucagon-stimulated adenylate cyclase activity.

腺苷对从PVG/c大鼠制备的肝细胞膜上胰高血糖素刺激的腺苷酸环化酶活性的抑制作用，可被胰岛素增强。在EGTA存在的情况下，胰岛素的这种增强作用消失。2. 钙（10微摩尔）增强了腺苷和胰岛素对胰高血糖素刺激的环化酶活性的抑制作用。从使用腺苷脱氨酶的情况判断，钙+胰岛素的协同作用需要腺苷的存在。3. 胰岛素对从幼年Wistar大鼠制备的肝细胞膜上胰高血糖素刺激的环化酶活性没有显著抑制作用，除非外部添加腺苷（50微摩尔）和钙（10微摩尔）。4. 结果表明，在膜水平上钙和胰岛素存在相互作用，在腺苷存在的情况下，这种相互作用导致胰高血糖素刺激的腺苷酸环化酶活性受到抑制。

Eur J Biochem. 1979 Apr;95(3):607-11. doi: 10.1111/j.1432-1033.1979.tb13001.x.

The inhibitory effect of adenosine on the glucagon-stimulated adenylate cyclase activity of liver plasma membranes, prepared from PVG/c rats, was potentiated by insulin. In the presence of EGTA, such potentiating effect of insulin was lost. 2. Calcium (10 microM) potentiated the inhibitory effects of both adenosine and insulin on the glucagon-stimulated cyclase activity. The synergestic effect of calcium + insulin required the presence of adenosine as judged from the use of adenosine deaminase. 3. Insulin had no significant inhibitory effect on the glucagon-stimulated cyclase activity of liver plasma membranes, prepared from young Wistar rats, unless both adenosine (50 microM) and calcium (10 microM) were added externally. 4. Results demonstrate an interaction of calcium and insulin at membrane level that, in the presence of adenosine, results in the inhibition of the glucagon-stimulated adenylate cyclase activity.

腺苷对从PVG/c大鼠制备的肝细胞膜上胰高血糖素刺激的腺苷酸环化酶活性的抑制作用，可被胰岛素增强。在EGTA存在的情况下，胰岛素的这种增强作用消失。2. 钙（10微摩尔）增强了腺苷和胰岛素对胰高血糖素刺激的环化酶活性的抑制作用。从使用腺苷脱氨酶的情况判断，钙+胰岛素的协同作用需要腺苷的存在。3. 胰岛素对从幼年Wistar大鼠制备的肝细胞膜上胰高血糖素刺激的环化酶活性没有显著抑制作用，除非外部添加腺苷（50微摩尔）和钙（10微摩尔）。4. 结果表明，在膜水平上钙和胰岛素存在相互作用，在腺苷存在的情况下，这种相互作用导致胰高血糖素刺激的腺苷酸环化酶活性受到抑制。