新型镇痛药dl-赤藓醇-1-苯基-2-（邻氯苯基）-2-[4-（对甲氧基苄基）-1-哌嗪基]乙醇二盐酸盐在实验动物中的药理学研究
Pharmacological studies of a new analgesic, dl-erythro-1-phenyl-2-(o-chlorophenyl)-2-[4-(p-methoxybenzyl)-1-piperazinyl] ethanol dihydrochloride, in experimental animals.
作者信息
Nakamura H, Ishii K, Yokoyama Y, Motoyoshi S, Imazu C, Shimizu M
出版信息
Experientia. 1979 Mar 15;35(3):369-70. doi: 10.1007/BF01964358.
PMID:446620
Abstract
dl-Erythro-1-phenyl-2-(o-chlorophenyl)-2-[4-(p-methoxybenzyl)-1-piperazinyl] ethanol dihydrochloride showed orally a definite analgesic activity, without producing the significant morphine-like physical dependence liability, and its analgesic potency was about a half that of codeine and far superior to aminopyrine in experimental animals.
摘要
dl-赤藓醇-1-苯基-2-(邻氯苯基)-2-[4-(对甲氧基苄基)-1-哌嗪基]乙醇二盐酸盐经口服显示出一定的镇痛活性，不会产生明显的类吗啡身体依赖性，并且在实验动物中其镇痛效力约为可待因的一半，远优于氨基比林。
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