分离出的IgG和IgM抗γ球蛋白（类风湿因子）的免疫学特性。
Immunological properties of isolated IgG and IgM anti-gamma-globulins (rheumatoid factors).
作者信息
Bianco N E, Dobkin L W, Schur P H
出版信息
Clin Exp Immunol. 1974 May;17(1):91-101.
Abstract
Anti-gamma-globulins of the IgG and IgM classes have been isolated from sera of normal individuals and from patients with osteoarthritis, rheumatoid arthritis and juvenile rheumatoid arthritis. All of the isolated antibodies gave precipitin curves with heat-aggregated, reduced and alkylated gamma-globulin. IgM anti-gamma-globulins gave a positive latex fixation test at 4°C and 37°C while IgG anti-gamma-globulins generally gave a positive test only at 4°C. Anti-gamma-globulins from normals did not fix complement but IgG and IgM anti-gamma-globulins from rheumatoids fixed complement to a similar degree. This complement fixation could account at least in part for the diminished complement levels seen in many rheumatoid synovial effusions.
摘要
已从正常个体以及骨关节炎、类风湿性关节炎和青少年类风湿性关节炎患者的血清中分离出IgG和IgM类抗γ球蛋白。所有分离出的抗体与热聚集、还原和烷基化的γ球蛋白均产生沉淀素曲线。IgM抗γ球蛋白在4°C和37°C时乳胶固定试验呈阳性，而IgG抗γ球蛋白通常仅在4°C时呈阳性。正常人的抗γ球蛋白不固定补体，但类风湿患者的IgG和IgM抗γ球蛋白固定补体的程度相似。这种补体固定至少可以部分解释许多类风湿性滑膜积液中补体水平降低的现象。
相似文献
1
Immunological properties of isolated IgG and IgM anti-gamma-globulins (rheumatoid factors).分离出的IgG和IgM抗γ球蛋白（类风湿因子）的免疫学特性。
Clin Exp Immunol. 1974 May;17(1):91-101.
2
3
4
Abnormalities in the distribution of serum immunoglobulin concentrations in juvenile rheumatoid arthritis.青少年类风湿关节炎患者血清免疫球蛋白浓度分布异常。
J Clin Invest. 1973 Aug;52(8):1931-6. doi: 10.1172/JCI107377.
5
7S IgG rheumatoid factor and hidden 19S IgM rheumatoid factor in juvenile chronic arthritis.青少年慢性关节炎中的7S IgG类风湿因子和隐匿性19S IgM类风湿因子。
Allergol Immunopathol (Madr). 1993 Sep-Oct;21(5):197-200.
6
7
[Immunohistochemical detection of tissue-bound rheumatoid factors (author's transl)].组织结合类风湿因子的免疫组织化学检测（作者译）
Acta Histochem Suppl. 1980;22:313-6.
8
Gamma globulin complexes in rheumatoid arthritis and hypergammaglobulinemic purpura.类风湿性关节炎和高丙种球蛋白血症性紫癜中的γ球蛋白复合物
J Rheumatol. 1974 Mar;1(1):54-65.
9
Hidden rheumatoid factor in latex negative test sera of patients with rheumatoid arthritis.类风湿关节炎患者乳胶试验阴性血清中的隐匿性类风湿因子。
Rev Bras Pesqui Med Biol. 1974 Jul-Aug;7(4):435-7.
10
Characterization of the gamma-globulin complexes present in certain sera having high titers of anti-gamma-globulin activity.对某些具有高滴度抗γ球蛋白活性血清中存在的γ球蛋白复合物的特性分析。
J Clin Invest. 1966 Apr;45(4):501-12. doi: 10.1172/JCI105364.
引用本文的文献
1
Rheumatoid factor as a potentiator of anti-citrullinated protein antibody-mediated inflammation in rheumatoid arthritis.类风湿因子作为类风湿关节炎中抗瓜氨酸化蛋白抗体介导炎症的增强剂。
Arthritis Rheumatol. 2014 Apr;66(4):813-21. doi: 10.1002/art.38307.
2
IgG and IgM rheumatoid factor in active seronegative nodular rheumatoid arthritis and in children with benign rheumatoid nodules.活动性血清阴性结节性类风湿关节炎及患良性类风湿结节儿童中的IgG和IgM类风湿因子
Clin Rheumatol. 1982 Jun;1(2):104-11. doi: 10.1007/BF02275599.
3
4
Effect of free radical altered IgG on allergic inflammation.自由基改变的免疫球蛋白G对变应性炎症的影响。
Ann Rheum Dis. 1987 Nov;46(11):866-74. doi: 10.1136/ard.46.11.866.
5
Complement-activating properties of immune complexes are suppressed by IgM rheumatoid factor and enhanced by IgG rheumatoid factor.免疫复合物的补体激活特性被IgM类风湿因子抑制，而被IgG类风湿因子增强。
Rheumatol Int. 1988;8(3):95-100. doi: 10.1007/BF00272429.
6
Clearance of cryoglobulins in man.人体中冷球蛋白的清除
Springer Semin Immunopathol. 1988;10(1):75-89. doi: 10.1007/BF02054025.
7
Laboratory diagnosis of rheumatoid arthritis: a solid phase radioassay for IgG and IgM antiglobulins.类风湿性关节炎的实验室诊断：一种检测IgG和IgM抗球蛋白的固相放射分析方法。
J Clin Pathol. 1976 Dec;29(12):1121-6. doi: 10.1136/jcp.29.12.1121.
8
Estimation of IgG-antiglobulins in sera of patients with rheumatoid arthritis and chronic liver disorders.类风湿性关节炎和慢性肝病患者血清中IgG抗球蛋白的测定。
Klin Wochenschr. 1976 Jul 1;54(13):601-6. doi: 10.1007/BF01469024.
9
Routine assay for detection of IgG and IgM antiglobulins in seronegative and seropositive rheumatoid arthritis.血清阴性和血清阳性类风湿性关节炎中IgG和IgM抗球蛋白检测的常规测定
Br Med J. 1975 Jul 26;3(5977):203-4. doi: 10.1136/bmj.3.5977.203.
10
A study of complement fixation by rheumatoid factor using a haemolytic assay system.使用溶血检测系统对类风湿因子补体结合的研究。
Clin Exp Immunol. 1977 May;28(2):204-11.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Biological activities of aggregated gamma globulin. I. Skin reactive and complement-fixing properties of heat denatured gamma globulin.聚合γ球蛋白的生物学活性。I. 热变性γ球蛋白的皮肤反应性和补体结合特性。
Proc Soc Exp Biol Med. 1959 Aug-Sep;101:845-50. doi: 10.3181/00379727-101-25116.
3
4
ACTIVITY OF DISSOCIATED AND REASSOCIATED 19S ANTI-GAMMA-GLOBULINS.解离和重新结合的19S抗γ球蛋白的活性
J Exp Med. 1964 Dec 1;120(6):1215-29. doi: 10.1084/jem.120.6.1215.
5
HEMOLYTIC COMPLEMENT IN SYNOVIAL FLUID.滑液中的溶血补体
J Clin Invest. 1964 Jul;43(7):1372-82. doi: 10.1172/JCI105013.
6
PEPSIN DIGESTION OF RABBIT AND SHEEP ANTIBODIES. THE EFFECT ON COMPLEMENT FIXATION.兔和羊抗体的胃蛋白酶消化作用。对补体结合的影响。
J Exp Med. 1963 Dec 1;118(6):891-904. doi: 10.1084/jem.118.6.891.
7
Low-molecular-weight rheumatoid factor.低分子量类风湿因子
J Clin Invest. 1963 Jun;42(6):876-84. doi: 10.1172/JCI104780.
8
Gamma globulin complexes in rheumatoid arthritis and certain other conditions.类风湿关节炎及某些其他病症中的γ球蛋白复合物
J Clin Invest. 1961 Jan;40(1):117-29. doi: 10.1172/JCI104224.
9
Serologic tests in rheumatoid arthritis.类风湿关节炎的血清学检测
Med Clin North Am. 1961 Sep;45:1181-96. doi: 10.1016/s0025-7125(16)33827-5.
10
Interaction of the rheumatoid factor with antigen-antibody complexes and aggregated gamma globulin.类风湿因子与抗原抗体复合物及聚集的γ球蛋白的相互作用。
J Exp Med. 1958 Jul 1;108(1):105-20. doi: 10.1084/jem.108.1.105.
Zotero 插件