胆绿素和康复龙对慢性肾衰竭患者降脂作用的研究。
Study of the lipid-lowering action of choloxin and nilevar in patients with chronic renal failure.
作者信息
Wardle E N, Schardt W, Uldall P R, Brown A, Jonfiah D, Moore A, Park R, Wood E
出版信息
Postgrad Med J. 1974 Dec;50(590):737-40. doi: 10.1136/pgmj.50.590.737.
Lowering of lipids in patients with chronic renal failure is advantageous but cannot be done by calorie restriction. In a controlled study the anabolic steroid norethandrolone (Nilevar) was found to lower triglycerides by 50%, while D-thyroxine (Choloxin) lowered the cholesterol by 25%. Both drugs increased the activity of lipoprotein lipase in spite of uraemic inhibition. Norethandrolone also reduced basal serum insulin levels. Norethandrolone seems appropriate for underweight patients and D-thyroxine for overweight patients, but side effects are more frequent than in non-uraemic patients.
降低慢性肾衰竭患者的血脂有益，但不能通过限制热量来实现。在一项对照研究中，发现合成代谢类固醇诺乙雄龙（尼罗瓦）可使甘油三酯降低50%，而D-甲状腺素（胆氯烯）可使胆固醇降低25%。尽管存在尿毒症抑制作用，但这两种药物均能增加脂蛋白脂肪酶的活性。诺乙雄龙还能降低基础血清胰岛素水平。诺乙雄龙似乎适用于体重过轻的患者，而D-甲状腺素适用于超重患者，但副作用比非尿毒症患者更常见。
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