Frankel B J, Grodsky G M
Diabetes. 1979 Jun;28(6):544-7. doi: 10.2337/diab.28.6.544.
In an attempt to prevent the onset of diabetes, young, genetically prediabetic (but not yet hyperglycemic) Chinese hamsters were treated continuously with insulin via minipump for 4 wk beginning 1 wk before the predicted age of onset of glucosuria (age 7 wk). Continuous insulin infusion which increased the plasma insulin levels by 70%, did not cause hypoglycemia, nor did it reduce the incidence or severity of diabetic symptoms over the ensuing year of observation. In fact, early treatment with exogenous insulin tended to cause increased hyperglycemia and glucosuria. No plasma anti-insulin antibodies were detected 3 and 9 months after stopping insulin treatment.
为了预防糖尿病的发生，在预计出现糖尿的年龄（7周龄）前1周开始，通过微型泵对年轻的、具有糖尿病遗传易感性（但尚未出现高血糖）的中国仓鼠连续4周给予胰岛素治疗。持续输注胰岛素使血浆胰岛素水平提高了70%，既未导致低血糖，在随后一年的观察中也未降低糖尿病症状的发生率或严重程度。事实上，早期给予外源性胰岛素治疗往往会导致高血糖和糖尿加重。停止胰岛素治疗3个月和9个月后，未检测到血浆抗胰岛素抗体。
