Stacher G, Schmierer G, Landgraf M
Gastroenterology. 1979 Jul;77(1):49-54.
"Spontaneous" tertiary esophageal contractions occur in a high proportion of healthy subjects. This study was carried out to investigate whether such contractions can be elicited by acoustical stimuli, to determine the threshold intensity at which contractions occur, and to find out how many of a sequence of equiintense tones at such a threshold intensity evoke contractile responses. Esophageal pressures were recorded 5, 10, and 15 cm above the lower esophageal sphincter, and swallowing was recorded by an electromyogram of the mylo-hyoid muscles. The results are summarized as follows: (a) All of 22 subjects exposed to 1000 Hz tones of intensities between 70 and 125 dBA responded with teritary contractions; their mean threshold intensity was 86.8 dBA +/- 3.0 SEM. Intensities that were 5 to 20 dBA higher were necessary to evoke contractions also in response to a second tone of a given intensity. (b) In 36 to 40 subjects exposed to 40 1000 Hz, 90 dBA tones tertiary contractions occurred in response to 47.2% of stimuli presented. (c) On repetitive stimulation, there was a significant decrease in number and amplitude of esophageal responses with an increasing number of stimuli. It is concluded that the esophagus takes part in the response system of the healthy organism to environmental stimuli.
“自发性”第三期食管收缩在很大比例的健康受试者中出现。本研究旨在调查这种收缩是否可由声学刺激诱发，确定出现收缩的阈值强度，并查明在该阈值强度下一系列等强度音调中有多少能引发收缩反应。在食管下括约肌上方5厘米、10厘米和15厘米处记录食管压力，通过下颌舌骨肌的肌电图记录吞咽情况。结果总结如下：(a) 22名受试者暴露于强度在70至125分贝声压级之间的1000赫兹音调时，均出现第三期收缩；其平均阈值强度为86.8分贝声压级±3.0标准误。对于给定强度的第二个音调，要诱发收缩，强度需高出5至20分贝声压级。(b) 在36至40名受试者暴露于40次1000赫兹、90分贝声压级的音调时，47.2%的刺激呈现后出现第三期收缩。(c) 在重复刺激时，随着刺激次数增加，食管反应的数量和幅度显著减少。结论是，食管参与了健康机体对环境刺激的反应系统。
