Growth hormone deficiency with hypoglycemia, genital hypoplasia and frontal prominence.

A boy with neonatal hypoglycemia, genital hypoplasia and frontal prominence ahd recurrence of hypoglycemic seizures at age 17 months. There was no plasma growth hormone (GH) response to sleep, arginine, hypoglycemia or glucagon. Mild secondary hypothroidism and primary hypogonadism were demonstrated. Small dose testosterone therapy for three months resulted in normal penile size; weekly injections of GH accelerated linear growth to a normal pace. Whether this complex represents a true syndrome or part of the spectrum of panhypopituitarism remains to be answered.