Weinerman B, Maxwell I, Hryniuk W
Can Med Assoc J. 1974 Nov 16;111(10):1100-2.
Cyclophosphamide was given intermittently rather than daily to 14 patients with autoimmune thrombocytopenic purpura. Eight patients responded and six did not. In those who responded the rise in platelet count was rapid, and in all patients the lack of toxicity was striking. Intermittent cyclophosphamide seems effective in some cases of autoimmune thrombocytopenia and is safe, at least in the short term. Controlled trials would be required to prove that intermittent is better than daily administration.
对14例自身免疫性血小板减少性紫癜患者间歇性而非每日给予环磷酰胺治疗。8例患者有反应，6例无反应。有反应的患者血小板计数迅速上升，且所有患者的毒性反应均不明显。间歇性环磷酰胺在某些自身免疫性血小板减少症病例中似乎有效且安全，至少在短期内如此。需要进行对照试验以证明间歇性给药优于每日给药。
