Geslin P, Marchadier J M, Dublanchet A, Legrand P, Borderon J C, Durieux R, Witchitz J, Bure A
Pathol Biol (Paris). 1979 Nov;27(9):571-8.
For a period of 17 months, 670 pneumococci, mostly isolated in the Paris area, have been typed with contercurrent-immunoelectrophoresis ; 338 of them come from cases of pneumonia, bacteremia, meningitis and acute otitis media. An important regrouping of the most frequent serotypes among the 83 known serotypes makes possible a vaccinal prophylaxis. The tetradecavalent vaccine which is now for sale in USA gives, in the four main pathologies of this enquiry, a coverage superior to 80 percent. Choosing the 14 most frequent serotypes of the four main pathologies of their data the authors propose the following vaccinal formula : 1, 3, 4, 5, 6, 7, 8, 10, 12, 14, 15, 18, 19, 23.
在17个月的时间里,对670株肺炎球菌(大多分离自巴黎地区)进行了对流免疫电泳分型;其中338株来自肺炎、菌血症、脑膜炎和急性中耳炎病例。在83种已知血清型中,最常见血清型的重要重新分组使疫苗预防成为可能。目前在美国销售的十四价疫苗在本调查的四种主要病症中覆盖率超过80%。根据其数据中四种主要病症的14种最常见血清型,作者提出了以下疫苗配方:1、3、4、5、6、7、8、10、12、14、15、18、19、23。