Müntzing J, Kirdani R Y, Murphy G P, Sandberg A A
Invest Urol. 1979 Jul;17(1):37-41.
A transplantable, metastasizing prostatic adenocarcinoma (Tumor I) in Lobund Wistar rats was examined for activity and distribution of five hydrolytic enzymes and for ability to accumulate radioactive zinc. The results suggest that the tumor had arisen in the ventral lobe of the prostate and that its growth was not affected by orchiectomy, adrenalectomy, or replacement treatment with exogenous androgen or corticosteroids. The androgen independency of the tumor was further shown by the low uptake of 3H-testosterone, in contrast to the high uptake in the ventral prostate. Tumor growth was retarded by Cytoxan but not by 5-fluorouracil, Estracyt, or streptozotocin, three agents clinically effective in the treatment of some patients with prostatic cancer resistant to endocrine therapy. It is concluded that this tumor in Lobund Wistar rats may be an adequate model for human prostatic cancers resistant to the agents mentioned above.
对Lobund Wistar大鼠体内一种可移植、转移性前列腺腺癌（肿瘤I）进行了研究，检测了五种水解酶的活性和分布以及积累放射性锌的能力。结果表明，该肿瘤起源于前列腺腹叶，其生长不受睾丸切除、肾上腺切除或外源性雄激素或皮质类固醇替代治疗的影响。与腹侧前列腺中高摄取相比，肿瘤对3H-睾酮的摄取较低，进一步表明该肿瘤具有雄激素非依赖性。环磷酰胺可抑制肿瘤生长，但5-氟尿嘧啶、癌腺治或链脲佐菌素则无此作用，这三种药物在临床上对一些内分泌治疗耐药的前列腺癌患者有效。得出的结论是，Lobund Wistar大鼠体内的这种肿瘤可能是对上述药物耐药的人类前列腺癌的合适模型。
