Cestonaro G, Emanuelli G, Calcamuggi G, Anfossi G, Gatti G
Invest Urol. 1979 Jul;17(1):46-9.
The lactate dehydrogenase isoenzyme pattern of different zones of rat kidney has been investigated at different stages after unilateral ureteral obstruction. In the obstructed kidney, the cortical tissue showed an early (3 days) progressive shift toward a cathodic zymogram; at 7 days LDH-5 isoenzyme was the predominant fraction (44.7 +/- 2.5). In the outer medullary tissue a similar change was observed even though middle fractions were always quite evident. No significant changes were found in the inner medullary tissue. The observed enzymatic abnormalities are related to renal hypoxia and to the occurrence of a less differentiated nephronic cell population. They represent a metabolic marker of the morphologic and functional alterations which occur in obstructive nephropathy.
在单侧输尿管梗阻后的不同阶段，对大鼠肾脏不同区域的乳酸脱氢酶同工酶谱进行了研究。在梗阻的肾脏中，皮质组织早期（3天）向阴极酶谱呈现渐进性转变；7天时，LDH-5同工酶是主要组分（44.7±2.5）。在外髓质组织中观察到类似变化，尽管中间组分始终相当明显。在内髓质组织中未发现显著变化。观察到的酶异常与肾缺氧以及分化程度较低的肾单位细胞群的出现有关。它们代表了梗阻性肾病中发生的形态学和功能改变的代谢标志物。
