慢性给药期间及停用吗啡后，微量离子导入法给予大鼠吗啡及递质物质的效应。
The effects of microiontophoretically applied morphine and transmitter substances in rats during chronic treatment and after withdrawl from morphine.
作者信息
Bradley P B, Dray A
出版信息
Br J Pharmacol. 1974 May;51(1):104-6. doi: 10.1111/j.1476-5381.1974.tb09638.x.
The effects of microiontophoretically applied acetylcholine, noradrenaline, 5-hydroxytryptamine and morphine were studied on single brain stem neurones of rats during chronic morphine pretreatment and 24 h after its withdrawal. No significant changes were observed in the initial spontaneous neuronal firing rate or in the qualitative or quantitative effects of acetylcholine, noradrenaline or 5-hydroxytryptamine. However, in chronically treated animals there was a significant decrease in the number of neurones excited by morphine or showing tachyphylaxis to morphine on repeated microiontophoretic applications.We suggest that some of the cellular central nervous system changes which occur during chronic morphine treatment are reflected by the decrease in sensitivity of neurones to morphine excitation.
研究了慢性吗啡预处理期间及撤药24小时后，微量离子电泳施加乙酰胆碱、去甲肾上腺素、5-羟色胺和吗啡对大鼠单脑干神经元的影响。未观察到初始自发神经元放电率或乙酰胆碱、去甲肾上腺素或5-羟色胺的定性或定量效应有显著变化。然而，在慢性处理的动物中，经反复微量离子电泳施加后，由吗啡兴奋或对吗啡表现出快速耐受性的神经元数量显著减少。我们认为，慢性吗啡治疗期间发生的一些细胞中枢神经系统变化反映在神经元对吗啡兴奋的敏感性降低上。
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