受体脱敏对α-银环蛇毒素作用于培养骨骼肌的影响。
The effect of receptor desensitization on the action of alpha-bungaro-toxin on cultured skeletal muscle.
作者信息
Dryden W F, Harvey A L
出版信息
Br J Pharmacol. 1974 Jul;51(3):456-8. doi: 10.1111/j.1476-5381.1974.tb10683.x.
Abstract
The effect of receptor desensitization produced by carbachol on the antagonist action of alpha-bungarotoxin has been studied in cultured skeletal muscle from chick embryos. In control preparations, alpha-bungarotoxin irreversibly blocked depolarization produced by carbachol. However, after receptor desensitization, alpha-bungarotoxin was no longer effective in blocking the response to carbachol. It is concluded that desensitization protects cholinoceptors from the action of alpha-bungarotoxin.
摘要
已在鸡胚培养的骨骼肌中研究了卡巴胆碱产生的受体脱敏对α-银环蛇毒素拮抗作用的影响。在对照制剂中，α-银环蛇毒素不可逆地阻断了卡巴胆碱产生的去极化。然而，受体脱敏后，α-银环蛇毒素不再能有效阻断对卡巴胆碱的反应。得出的结论是，脱敏可保护胆碱能受体免受α-银环蛇毒素的作用。
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