Smals A G, Pieters G F, Drayer J I, Benraad T J, Kloppenborg P W
J Clin Endocrinol Metab. 1979 Jul;49(1):12-4. doi: 10.1210/jcem-49-1-12.
A single im injection of 1500 IU hCG significantly increased plasma testosterone levels for at least 96--120 h in normal men (n = 7), patients with isolated gonadotropin deficiency (n = 6), and boys with delayed puberty (n = 7); the maximum values [1315 +/- 309, 370 +/- 177, and 963 +/- 249 ng/100 ml (mean +/- SD), respectively] were achieved after 72 h in each group. Repeated daily injections of 1500 IU hCG for 3 days increased plasma testosterone levels in the same subjects at 72 h after the start to levels (1342 +/- 412, 407 +/- 199, and 1052 +/- 449 ng/100 ml, respectively) similar to those found in the single dose experiment. The levels achieved at 24 and 48 h also did not differ significantly in the two experiments. The data indicate the lack of additional leydig cell stimulation by repeated hCG injections given within 48 h after a single dose.
单次肌肉注射1500国际单位人绒毛膜促性腺激素（hCG）可使正常男性（n = 7）、孤立性促性腺激素缺乏患者（n = 6）和青春期延迟男孩（n = 7）的血浆睾酮水平显著升高至少96 - 120小时；每组在72小时后达到最大值[分别为1315±309、370±177和963±249纳克/100毫升（均值±标准差）]。在同一受试者中，连续3天每日重复注射1500国际单位hCG，在开始注射后72小时时血浆睾酮水平升高至（分别为1342±412、407±199和1052±449纳克/100毫升），与单次剂量实验中的水平相似。在这两个实验中，24小时和48小时时达到的水平也无显著差异。数据表明，在单次剂量后48小时内重复注射hCG不会对睾丸间质细胞产生额外刺激。
