Ottesen E A, Weller P F
J Infect Dis. 1979 Mar;139(3):343-7. doi: 10.1093/infdis/139.3.343.
Eosinophilia is frequently observed after treatment of patients with infections due to parasitic helminths. For definition of the characteristics and causes of post-treatment eosinophilic responses, 47 patients with Bancroft's filariasis, who were treated with diethylcarbamazine, and eight patients with schistosomiasis mansoni, who were treated with niridazole, were studied. After therapy for eight days, both groups developed significant (P less than 0.05) increases in their levels of eosinophilia, which peaked in two to four weeks. Maximal levels averaged two and one-half to three time the levels before treatment. Before therapy the number of circulating eosinophils was unrelated to intensity of infection in both groups, but after treatment, when the same relationship was examined in the larger group (the patients with filariasis), the degree of post-treatment eosinophilia was significantly correlated with the patients' worm burdens before treatment (r = 0.727; P less than 0.001). Thus, treatment of helminthic infections can provide a unique opportunity for studying eosinophil responses of humans to graded doses of antigen and has shown that acute responses are determined quantitatively by the amount of antigen initially presented to the host.
在使用抗寄生虫蠕虫药物治疗感染患者后，经常会观察到嗜酸性粒细胞增多的现象。为了明确治疗后嗜酸性粒细胞反应的特征和原因，对47例接受乙胺嗪治疗的班氏丝虫病患者和8例接受硝唑咪治疗的曼氏血吸虫病患者进行了研究。治疗八天后，两组患者的嗜酸性粒细胞水平均显著升高（P<0.05），并在两到四周内达到峰值。最高水平平均为治疗前的二点五到三倍。治疗前，两组患者循环嗜酸性粒细胞的数量与感染强度无关，但在治疗后，对较大的一组（丝虫病患者）进行同样关系的检查时，治疗后嗜酸性粒细胞增多的程度与患者治疗前的虫负荷显著相关（r=0.727；P<0.001）。因此，蠕虫感染的治疗为研究人类对分级剂量抗原的嗜酸性粒细胞反应提供了一个独特的机会，并表明急性反应在数量上由最初呈现给宿主的抗原量决定。
