Olanoff L S, Mahmound A A, Anderson J M
Am J Trop Med Hyg. 1980 Jan;29(1):71-3. doi: 10.4269/ajtmh.1980.29.71.
Niridazole was incorporated into silicone rubber implants to investigate the potential of a sustained release of the drug in the therapy of murine schistosomiasis mansoni. The infected animals (200 cercariae for 6 weeks) were randomly divided into three groups: one group received silicone rubber implants containing 50% by weight niridazole; a second group received blank silicone rubber implants with no drug; and the third group received no implants. Mortality 4 weeks later was in excess of 80% for animals with no implants or with the blank silicone rubber implants. In contrast, 10% mortality was observed in the mice receiving the niridazole-silicone rubber implants over a 10-week period. The worm burden in the niridazole-silicone rubber implant group was reduced at 10 weeks post implantation by 77%.
将硝唑咪掺入硅橡胶植入物中，以研究该药物持续释放用于治疗小鼠曼氏血吸虫病的潜力。受感染动物（200只尾蚴感染6周）被随机分为三组：一组接受含50%（重量）硝唑咪的硅橡胶植入物；第二组接受不含药物的空白硅橡胶植入物；第三组不接受植入物。4周后，未植入或接受空白硅橡胶植入物的动物死亡率超过80%。相比之下，接受硝唑咪-硅橡胶植入物的小鼠在10周内的死亡率为10%。植入硝唑咪-硅橡胶植入物组在植入后10周时虫负荷降低了77%。
