2',3'-双（2-氯乙基）氨基磷酰基-3'-氨基-3'-脱氧腺苷：一种具有抗肿瘤活性的环核苷酸。
2',3'-Bis(2-chloroethyl)aminophosphoryl-3'-amino-3'-deoxyadenosine: a cyclic nucleotide with antitumor activity.
作者信息
Okruszek A, Verkade J G
出版信息
J Med Chem. 1979 Jul;22(7):882-5. doi: 10.1021/jm00193a026.
PMID:448687
Abstract
The synthesis of the title compound from 3'-amino-3'-deoxyadenosine in 40% yield is reported. 3'-Amino-3'-deoxyadenosine was made by an improved synthesis in 12 steps from inexpensive D-xylose in 15% overall yield. Both isomers of the title compound, separated by column chromatography, possess confirmed activity against KB tumor cell cultures.
摘要
据报道，由3'-氨基-3'-脱氧腺苷合成标题化合物，产率为40%。3'-氨基-3'-脱氧腺苷通过改进的合成方法，以廉价的D-木糖为原料，经12步反应制得，总产率为15%。通过柱色谱分离得到的标题化合物的两种异构体均对KB肿瘤细胞培养物具有确定的活性。
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