Goldstein E J, Lewis R P, Sutter V L, Finegold S M
JAMA. 1979 Aug 3;242(5):435-8.
Erythromycin has been reported to be active in vitro against most anaerobic bacteria. We found it effective in treating 14 of 17 patients with mild to moderately severe anaerobic or mixed aerobic/anaerobic pleuropulmonary of soft-tissue infections when adjunctive measures (eg, drainage, débridement, and the use of additional antibiotics to treat important aerobic pathogens) were employed. Erythromycin offers a reasonable therapeutic alternative to penicillin in the treatment of a penicillin-allergic patient who has a mild or moderately severe anaerobic or mixed aerobic/anaerobic infection not involving Bacteroides fragilis or fusobacteria.
据报道，红霉素在体外对大多数厌氧菌具有活性。我们发现，在采取辅助措施（如引流、清创以及使用其他抗生素治疗重要的需氧病原体）时，红霉素对17例患有轻度至中度严重厌氧或需氧/厌氧混合性胸膜肺部或软组织感染的患者中的14例有效。对于患有轻度或中度严重厌氧或需氧/厌氧混合性感染且不涉及脆弱拟杆菌或梭杆菌的青霉素过敏患者，红霉素是一种合理的治疗青霉素替代药物。
