Effect of preoperative intralesional BCG and postoperative 5-FU chemotherapy in three adenocarcinoma lines in rats.

In No. 13762 mammary adenocarcinoma, it has been shown that the combination of tumor infiltration with BCG and of subsequent surgery is more curative than either treatment modality alone. And the administration of postoperative systemic 5-fluorouracil (D-FU) is equally effective in eliminating the visceral metastasis and prolonging the host survival. In the experiments reported here, two other spontaneously metastasizing adenocarcinoma lines were similarly treated. Postoperative 5-FU chemotherapy, but not intralesional BCG, significantly improved survival duration of rats with SMT-2A mammary adenocarcinoma, but neither chemotherapy nor BCG immunotherapy was effective in the new colonic adenocarcinoma line.