Zotti S, Bergamo S, Maddalosso T, Salmi A
Arch Sci Med (Torino). 1979 Jul-Sep;136(3):363-8.
In 28 patients suffering from alcoholic well compensated hepatopathy, different laboratory parameters have been controlled before and after treatment with arginine thiazolidinecarboxylate, i.v. a the daily dose of 800 mg for 7-10 days. The compartmental analysis showed that the improvement in the BSF clearance is mainly due to a reduction in the "regurgitation fraction" and therefore to an improvement or restoration of the processes of conjugation, binding and transferring of the dye in the liver cells. A significant increase in platelets and an equally significant decrease in bilirubinemia, gamma GT, OCT, GOT and alkaline phosphatase were reported. Such variations might be at any rate due to the sole alcohol abstinence. The observed increase in transferrin, haptoglobin and albumin cannot be reported to the sole abstinence, but must be considered as consequence of the pharmacological influence, of arginine thiazolidinecarboxylate on the protidosynthetic activities of the liver.
对28例酒精性代偿良好的肝病患者，在静脉注射每日剂量800毫克的噻唑烷羧酸精氨酸治疗7至10天前后，对不同的实验室参数进行了对照。房室分析表明，胆汁酸分泌分数（BSF）清除率的改善主要是由于“反流分数”的降低，因此是由于肝细胞中染料结合、结合和转运过程的改善或恢复。据报道，血小板显著增加，胆红素血症、γ-谷氨酰转肽酶（gamma GT）、鸟氨酸氨基甲酰转移酶（OCT）、谷草转氨酶（GOT）和碱性磷酸酶同样显著降低。无论如何，这种变化可能仅仅是由于戒酒。观察到的转铁蛋白、触珠蛋白和白蛋白的增加不能仅仅归因于戒酒，而必须被视为噻唑烷羧酸精氨酸对肝脏蛋白质合成活性的药理作用的结果。
