Montanini R, Basso P F, Gasco P
Minerva Med. 1979 Apr 30;70(21):1551-3.
The result about Levodopa treatment in torsion dystonia and athetosis are quite contradictory. We report an interesting case, significant for the results that we obtained in a long treatment period. A girl was suffering from age of 8 years of torsion dystonia associated with athetosis. We made our first clinical examination when 12 years old: she was not able to stand-up and to walking, neither was she able to be sitting in a chair without arms. In two months of treatment with Levodopa 3.000 mg. by day, the symptoms completely disappeared. During the first two years of treatment, at every effort to decrease the therapy we observed an important increase of symptoms. Successively it was possible to decrease the therapy and now, after 8 years of treatment, with a minimal dose, the girl doesn't show any symptoms, so that she can manage a normal relative life. Probably these good results depend on the fact that was a sporadic recessive form of torsion dystonia case.
左旋多巴治疗扭转性肌张力障碍和手足徐动症的结果颇为矛盾。我们报告一个有趣的病例，因其在长期治疗中所获结果具有重要意义。一名女童8岁起患扭转性肌张力障碍并伴有手足徐动症。我们在她12岁时进行了首次临床检查：她无法站立和行走，坐在没有扶手的椅子上也不行。在每日服用3000毫克左旋多巴治疗两个月后，症状完全消失。在治疗的头两年，每次尝试减少治疗剂量时，我们都观察到症状显著加重。随后能够减少治疗剂量，如今，经过8年治疗，使用最小剂量，该女童未出现任何症状，能够过上正常的相对独立生活。这些良好结果可能取决于这是一例散发性隐性扭转性肌张力障碍病例。
