Johnson L D, Driscoll S G, Hertig A T, Cole P T, Nickerson R J
Obstet Gynecol. 1979 Jun;53(6):671-9.
A histologic study was conducted of sagittal sections of the genital tracts of 281 autopsied female stillborns and neonates. The prevalence of vaginal adenosis among 43 offspring exposed in utero to diethylstilbestrol (DES) was 70%, a frequency 18 times greater than the 4% prevalence among 159 unexposed offspring. The relationship of the prevalence of vaginal adenosis to the gestational age at initial exposure was highly significant: 81% of those first exposed during the period of vaginogenesis had adenosis, whereas none exposed after 21 weeks' gestation had adenosis (P1 = 1 X 10(-4)). The relationship of the prevalence of vaginal adenosis to the total dose of DES prior to 22 weeks' gestation also was significant (P1 = 0.02), and this relationship was independent of gestational age at first exposure (P1 =0.01). In contrast, the prevalence of adenosis among 23 offspring exposed to steroidal estrogens and progestins was about the same as that among the unexposed offspring. Vaginal adenosis was unrelated to the complications of pregnancy for which the hormones were given, the calendar year of birth, and the gestational age at delivery.
对281例女性死产儿和新生儿尸体解剖的生殖道矢状切片进行了组织学研究。在43例子宫内暴露于己烯雌酚（DES）的后代中，阴道腺病的患病率为70%，这一频率比159例未暴露后代中4%的患病率高18倍。阴道腺病患病率与初次暴露时的胎龄之间的关系极为显著：在阴道形成期初次暴露的人中，81%患有腺病，而在妊娠21周后暴露的人中无人患腺病（P1 = 1×10⁻⁴）。阴道腺病患病率与妊娠22周前DES的总剂量之间的关系也很显著（P1 = 0.02），并且这种关系与初次暴露时的胎龄无关（P1 = 0.01）。相比之下，23例暴露于甾体雌激素和孕激素的后代中腺病的患病率与未暴露后代中的患病率大致相同。阴道腺病与给予激素所针对的妊娠并发症、出生年份以及分娩时的胎龄无关。
