关于维生素B₁₂的作用机制。模型研究。3,3 - 二甲基乙醇酸甲酯向乙酰丙酸甲酯的热重排。
On the mechanism of action of vitamin B 12 . Model studies. Thermal rearrangement of methyl 3,3-dimethylglycidate to methyl levulinate.
作者信息
Dowd P, Nakagawa C S
出版信息
Proc Natl Acad Sci U S A. 1972 May;69(5):1173-5. doi: 10.1073/pnas.69.5.1173.
Abstract
The discovery that methyl 3,3-dimethylglycidate rearranges to methyl levulinate on heating is discussed in terms of its possible consequences for the mechanism of action of the coenzyme B(12)-dependent enzymes: methylmalonyl-CoA mutase (EC 5.4.99.2), glutamate mutase (EC 5.4.99.1), and a-methyleneglutarate mutase. It is also suggested that the proposed mechanism may provide a unifying link between the mechanism of action of the above enzymes and that of the coenzyme B(12)-dependent dioldehydrase and related enzymes.
摘要
3,3 - 二甲基乙醇酸甲酯在加热时重排为乙酰丙酸甲酯这一发现，从其对依赖辅酶B(12)的酶（甲基丙二酰辅酶A变位酶（EC 5.4.99.2）、谷氨酸变位酶（EC 5.4.99.1）和α - 亚甲基戊二酸变位酶）作用机制的可能影响方面进行了讨论。还提出所提出的机制可能为上述酶与依赖辅酶B(12)的二醇脱水酶及相关酶的作用机制之间提供一个统一的联系。
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