视觉发色团及相关色素的结构：视觉激发的构象基础。

Structures of the visual chromophores and related pigments: a conformational basis of visual excitation.

作者信息

Sundaralingam M, Beddell C

出版信息

Proc Natl Acad Sci U S A. 1972 Jun;69(6):1569-73. doi: 10.1073/pnas.69.6.1569.

DOI:10.1073/pnas.69.6.1569

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC426750/

Abstract

A detailed conformational analysis of the known crystal structures of vitamin A, carotenoid, and xanthenoid derivatives has been made. These studies suggest that the visual chromophore 11-cis retinal and its isomers may each occur in several different conformational states, which would be expected to have different lightabsorbing characteristics. The presence of such states for 11-cis retinal and all-trans retinal may contribute to the observed rhodopsin intermediates that have been characterized by different lambda(max) values, and to the breadth of spectral response in scotopic and color vision.

摘要

已对维生素A、类胡萝卜素和呫吨类衍生物的已知晶体结构进行了详细的构象分析。这些研究表明，视觉发色团11-顺式视黄醛及其异构体可能各自以几种不同的构象状态存在，预计这些状态具有不同的光吸收特性。11-顺式视黄醛和全反式视黄醛的这些状态的存在可能有助于观察到的视紫红质中间体，这些中间体已通过不同的最大吸收波长值进行了表征，并有助于暗视觉和色觉中的光谱响应宽度。

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本文引用的文献

1

THE ACTION OF LIGHT ON RHODOPSIN.

Proc Natl Acad Sci U S A. 1958 Feb;44(2):130-9. doi: 10.1073/pnas.44.2.130.

2

Crystal structure of the visual chromophores, 11-cis and all-trans retinal.

Nature. 1971 Jul 16;232(5307):187-9. doi: 10.1038/232187c0.

3

THE ROLE OF CARBONIUM IONS IN COLOR RECEPTION.

J Gen Physiol. 1965 May;48(5):753-60. doi: 10.1085/jgp.48.5.753.

4

A NEW RECEPTOR POTENTIAL OF THE MONKEY RETINA WITH NO DETECTABLE LATENCY.

Nature. 1964 Feb 8;201:626-8. doi: 10.1038/201626a0.

5

TAUTOMERIC FORMS OF METARHODOPSIN.

J Gen Physiol. 1963 Nov;47(2):215-40. doi: 10.1085/jgp.47.2.215.

6

The mechanism of bleaching rhodopsin.

Ann N Y Acad Sci. 1959 Nov 12;74(2):266-80. doi: 10.1111/j.1749-6632.1958.tb39550.x.

7

The lipoprotein nature of rhodopsin.

AMA Arch Ophthalmol. 1958 Oct;60(4 Part 2):688-94; discussion 694. doi: 10.1001/archopht.1958.00940080708014.

8

Location of the heme in horse heart ferricytochrome c by x-ray diffraction.

J Biol Chem. 1967 Jun 25;242(12):3015-8.

9

Lipid to protein chromophore transfer in the photolysis of visual pigments.

Nature. 1969 Jan 18;221(5177):256-7. doi: 10.1038/221256a0.

10

The crystal and molecular structure of canthaxanthin.

Acta Crystallogr B Struct Crystallogr Cryst Chem. 1968 Dec 15;24(12):1587-606. doi: 10.1107/s056774086800470x.

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