3,6-二脱氧己糖中3-脱氧基团的引入：磷酸吡哆胺-5'-磷酸的一种新的辅因子功能。
Introducting of the 3-deoxy group in 3,6-dideoxyhexoses: a novel cofactor function for pyridoxamine-5'-phosphate.
作者信息
Gonzalez-Porque P, Strominger J L
出版信息
Proc Natl Acad Sci U S A. 1972 Jun;69(6):1625-8. doi: 10.1073/pnas.69.6.1625.
A cofactor needed for the reduction of CDP-4-keto-6-deoxy-D-glucose to CDP-4-keto-3,6-dideoxy D-glucose has been detected and purified. Its spectra in neutral, acid, and basic solutions, its behavior on thin-layer chromatography, and other properties led to its identification as pyridoxamine-5'-phosphate. Moreover, authentic pyridoxamine-5'-phosphate substituted for the purified cofactor with about the same specific activity. Other vitamin B(6) derivatives did not stimulate the reaction, and inhibition was observed with some of them.
一种将CDP - 4 - 酮 - 6 - 脱氧 - D - 葡萄糖还原为CDP - 4 - 酮 - 3,6 - 二脱氧 - D - 葡萄糖所需的辅因子已被检测和纯化。其在中性、酸性和碱性溶液中的光谱、在薄层色谱上的行为以及其他特性使其被鉴定为磷酸吡哆胺 - 5'-磷酸。此外，用具有大致相同比活性的纯化辅因子替代了纯的磷酸吡哆胺 - 5'-磷酸。其他维生素B6衍生物不能刺激该反应，并且其中一些表现出抑制作用。
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