Camerman N, Camerman A
Proc Natl Acad Sci U S A. 1972 Aug;69(8):2130-1. doi: 10.1073/pnas.69.8.2130.
The biological importance of L-thyroxin, the principal hormone secreted by the thyroid gland, is well established, but the mechanisms of thyroid-hormone action are still largely unexplained. We have crystallized L-thyroxin and determined its three-dimensional structure by x-ray crystallography in the hope that comparison of structures of active and inactive thyroid-hormone analogues will shed some light on hormone mechanisms. We compare the conformation of L-thyroxin to that of triiodo-L-thyronine, a thyroid hormone with greater activity.
甲状腺分泌的主要激素L-甲状腺素的生物学重要性已得到充分证实，但甲状腺激素的作用机制在很大程度上仍未得到解释。我们已使L-甲状腺素结晶，并通过X射线晶体学确定了其三维结构，希望通过比较活性和非活性甲状腺激素类似物的结构，能为激素作用机制提供一些线索。我们将L-甲状腺素的构象与活性更强的甲状腺激素三碘-L-甲状腺原氨酸的构象进行了比较。
