Clegg M T, Allard R W, Kahler A L
Proc Natl Acad Sci U S A. 1972 Sep;69(9):2474-8. doi: 10.1073/pnas.69.9.2474.
The dynamics of gametic frequency change have been analyzed in two experimental plant populations. Individual plants were scored for their genotype at four enzyme loci, and four-locus joint gametic frequencies were estimated from the genotypic data over generations. Striking correlations developed in allelic state over loci, including correlations between nonlinked loci, as these populations evolved. Furthermore, the same pair of four-locus complementary gametic types came into marked excess in the late generations of both populations. The results demonstrate that natural selection acted to structure the genetic resources of these populations into sets of highly interacting, coadapted gene complexes. They also provide evidence, at the level of the gene, that selection operating on correlated multilocus units is an important determinant of population structure.
在两个实验植物种群中分析了配子频率变化的动态。对个体植物在四个酶位点的基因型进行了评分,并根据几代的基因型数据估计了四位点联合配子频率。随着这些种群的进化,在基因座的等位基因状态上出现了显著的相关性,包括非连锁基因座之间的相关性。此外,在两个种群的后期世代中,同一对四位点互补配子类型显著过剩。结果表明,自然选择作用于将这些种群的遗传资源构建成高度相互作用、共同适应的基因复合体。它们还在基因水平上提供了证据,表明对相关多位点单位进行选择是种群结构的一个重要决定因素。