Kauffmann K, Lee A J
J Hered. 1976 Jul-Aug;67(4):231-4. doi: 10.1093/oxfordjournals.jhered.a108716.
Selection changes the frequency of alleles at a linked locus as well as at those under selection if the population is not in linkage equilibrium. The magnitude of this frequency change depends on the tightness of the linkage, the selection intensity, and the deviation from linkage equilibrium. Allowing a population to mate randomly without selection brings the population closer to linkage equilibrium. This decreases the effect of selection on allelic frequencies at a linked neutral locus. However, if linkage is very tight it can take many generations to make a large difference in the effect of the linked locus. The loss due to undesirable changes in allelic frequencies at linked loci when the population is not in linkage equilibrium must be weighed against the time and effort saved by beginning intense selection for the primary trait in an early generation. Effects of selection intensity, linkage intensity, and delayed selection on changes in allelic frequency at a neutral linked locus are demonstrated.
如果群体不处于连锁平衡状态，选择会改变连锁位点以及受选择位点上等位基因的频率。这种频率变化的幅度取决于连锁的紧密程度、选择强度以及与连锁平衡的偏差。让群体在无选择的情况下随机交配会使群体更接近连锁平衡。这会降低选择对连锁中性位点上等位基因频率的影响。然而，如果连锁非常紧密，可能需要许多代才能使连锁位点的影响产生很大差异。当群体不处于连锁平衡状态时，由于连锁位点上等位基因频率的不良变化所导致的损失，必须与通过在早期世代开始对主要性状进行强烈选择所节省的时间和精力相权衡。文中展示了选择强度、连锁强度和延迟选择对中性连锁位点上等位基因频率变化的影响。
