卤代苯对大鼠乙酰苯胺酯酶、乙酰苯胺羟化酶和普鲁卡因酯酶的影响。

Effect of halogenated benzenes on acetanilide esterase, acetanilide hydroxylase and procaine esterase in rats.

作者信息

Carlson G P, Dziezak J D, Johnson K M

出版信息

Res Commun Chem Pathol Pharmacol. 1979 Jul;25(1):181-4.

Abstract

1,2,4-Trichlorobenzene, 1,3,5-trichlorobenzene, hexachlorobenzene, 1,2,4-tribromobenzene, 1,3,5-tribromobenzene and hexabromobenzene were compared for their abilities to induce acetanilide esterase, acentailide hydroxylase and procaine esterase. Except for hexabromobenzene all induced acetanilide esterase whereas the hydroxylation of acetanilide was seen only with the fully halogenated benzenes and with 1,3,5-tribromobenzene. Hepatic procaine esterase activity was increased by the three chlorinated benzenes and 1,2,4-tribromobenzene.

摘要

对1,2,4-三氯苯、1,3,5-三氯苯、六氯苯、1,2,4-三溴苯、1,3,5-三溴苯和六溴苯诱导乙酰苯胺酯酶、乙酰苯胺羟化酶和普鲁卡因酯酶的能力进行了比较。除六溴苯外，其他物质均能诱导乙酰苯胺酯酶，而乙酰苯胺的羟化作用仅在全卤代苯和1,3,5-三溴苯中观察到。三种氯苯和1,2,4-三溴苯可提高肝脏普鲁卡因酯酶的活性。