阿司匹林对镰状细胞血红蛋白的乙酰化作用。
Acetylation of sickle cell hemoglobin by aspirin.
作者信息
Klotz I M, Tam J W
出版信息
Proc Natl Acad Sci U S A. 1973 May;70(5):1313-5. doi: 10.1073/pnas.70.5.1313.
Abstract
Incubation of HbS (or HbA) with aspirin leads to incorporation of acetyl groups into the protein. Incorporation was followed by the use of aspirin labeled with (14)C in the acetyl group. The acetylated hemoglobins show an increase in oxygen affinity compared to the parent proteins. If acetylation also occurs in vivo, administration of aspirin might ameliorate the severity of sickle cell disease.
摘要
将血红蛋白S（或血红蛋白A）与阿司匹林一起温育会导致蛋白质中掺入乙酰基。通过使用乙酰基上标记有碳-14的阿司匹林来追踪掺入情况。与未乙酰化的蛋白质相比，乙酰化血红蛋白的氧亲和力有所增加。如果体内也发生乙酰化，那么服用阿司匹林可能会减轻镰状细胞病的严重程度。
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本文引用的文献
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