致命性铁中毒伴多种凝血缺陷及凝血因子VIII和因子XIII降解。
Fatal iron intoxication with multiple coagulation defects and degradation of factor VIII and factor XIII.
作者信息
Henriksson P, Nilsson L, Nilsson I M, Stenberg P
出版信息
Scand J Haematol. 1979 Mar;22(3):235-40. doi: 10.1111/j.1600-0609.1979.tb02802.x.
Abstract
A severe iron intoxication in a 15-year-old girl resulted in profound damage to vital organs and multiple clotting defects, but no haemorrhagic diathesis. Investigation revealed not only impaired synthesis of coagulation factors but also abnormal proteolysis by plasmin as well as by other proteolytic enzymes liberated from leucocytes and damaged tissue cells affecting especially factor VIII and factor XIII.
摘要
一名15岁女孩严重铁中毒，导致重要器官严重受损和多种凝血缺陷，但无出血素质。调查发现，不仅凝血因子合成受损，而且纤溶酶以及从白细胞和受损组织细胞释放的其他蛋白水解酶的异常蛋白水解也影响了凝血因子，尤其是凝血因子VIII和凝血因子XIII。
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