抗坏血酸对亚硝酸钠加氨基比林所致肝毒性的保护作用。
Protective effect of ascorbic acid on hepatotoxicity caused by sodium nitrite plus aminopyrine.
作者信息
Kamm J J, Dashman T, Conney A H, Burns J J
出版信息
Proc Natl Acad Sci U S A. 1973 Mar;70(3):747-9. doi: 10.1073/pnas.70.3.747.
Abstract
The oral treatment of rats with sodium ascorbate in combination with sodium nitrite and aminopyrine prevents the rise in serum alanine aminotransferase (EC 2.6.1.2) observed when nitrite and aminopyrine are given alone. Ascorbic acid also affords protection, whereas dehydroascorbic acid exerts no protective effect.
摘要
用抗坏血酸钠与亚硝酸钠及氨基比林联合对大鼠进行口服治疗，可防止单独给予亚硝酸钠和氨基比林时所观察到的血清丙氨酸转氨酶（EC 2.6.1.2）升高。抗坏血酸也具有保护作用，而脱氢抗坏血酸则无保护作用。
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4
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本文引用的文献
1
Symposium on metabolism of inorganic compounds. II. Enzymatic pathways of nitrate, nitrite, and hydroxylamine metabolisms.无机化合物代谢研讨会。II. 硝酸盐、亚硝酸盐和羟胺代谢的酶促途径。
Bacteriol Rev. 1962 Mar;26(1):16-41. doi: 10.1128/br.26.1.16-41.1962.
2
Nitrosamines as environmental carcinogens.亚硝胺作为环境致癌物。
Nature. 1970 Jan 3;225(5227):21-3. doi: 10.1038/225021a0.
3
Ascorbate-nitrite reaction: possible means of blocking the formation of carcinogenic N-nitroso compounds.抗坏血酸盐-亚硝酸盐反应：阻断致癌性N-亚硝基化合物形成的可能方法。
Science. 1972 Jul 7;177(4043):65-8. doi: 10.1126/science.177.4043.65.
4
Nitrates, nitrites, and nitrosamines.
Science. 1972 Jul 7;177(4043):15-9. doi: 10.1126/science.177.4043.15.
5
Toxicity of nitrosamines: their possible human health hazards.亚硝胺的毒性：它们对人类健康可能造成的危害。
Food Cosmet Toxicol. 1971 Apr;9(2):207-18. doi: 10.1016/0015-6264(71)90306-3.
6
Carcinogenic nitroso compounds.致癌亚硝基化合物。
Adv Cancer Res. 1967;10:163-246. doi: 10.1016/s0065-230x(08)60079-2.
7
Carcinogen dimethylnitrosamine produced in vivo from nitrite and aminopyrine.
Nat New Biol. 1972 Apr 12;236(67):177-8. doi: 10.1038/newbio236177a0.
8
A nitrate reductase from Micrococcus denitrificans.一种来自反硝化微球菌的硝酸还原酶。
Biochim Biophys Acta. 1969 Apr 22;178(2):225-34. doi: 10.1016/0005-2744(69)90392-1.
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