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抗坏血酸对亚硝酸钠加氨基比林所致肝毒性的保护作用。

Protective effect of ascorbic acid on hepatotoxicity caused by sodium nitrite plus aminopyrine.

作者信息

Kamm J J, Dashman T, Conney A H, Burns J J

出版信息

Proc Natl Acad Sci U S A. 1973 Mar;70(3):747-9. doi: 10.1073/pnas.70.3.747.

DOI:10.1073/pnas.70.3.747
PMID:4514987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC433349/
Abstract

The oral treatment of rats with sodium ascorbate in combination with sodium nitrite and aminopyrine prevents the rise in serum alanine aminotransferase (EC 2.6.1.2) observed when nitrite and aminopyrine are given alone. Ascorbic acid also affords protection, whereas dehydroascorbic acid exerts no protective effect.

摘要

用抗坏血酸钠与亚硝酸钠及氨基比林联合对大鼠进行口服治疗，可防止单独给予亚硝酸钠和氨基比林时所观察到的血清丙氨酸转氨酶（EC 2.6.1.2）升高。抗坏血酸也具有保护作用，而脱氢抗坏血酸则无保护作用。

相似文献

1
Protective effect of ascorbic acid on hepatotoxicity caused by sodium nitrite plus aminopyrine.抗坏血酸对亚硝酸钠加氨基比林所致肝毒性的保护作用。
Proc Natl Acad Sci U S A. 1973 Mar;70(3):747-9. doi: 10.1073/pnas.70.3.747.
2
Damage and repair of rat liver DNA by simultaneous oral administration of amines and nitrite.
Gan. 1976 Dec;67(6):819-23.
3
Effect of ascorbic acid on amine-nitrite toxicity.
Ann N Y Acad Sci. 1975 Sep 30;258:169-74. doi: 10.1111/j.1749-6632.1975.tb29276.x.
4
Brief communication: ascorbic acid blocking of aminopyrine nitrosation in NZO-B1 mice.
J Natl Cancer Inst. 1973 Apr;50(4):1055-6. doi: 10.1093/jnci/50.4.1055.
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Studies on nitrosamine formation by the interaction between drugs and nitrite. II. Hepatotoxicity by the simultaneous administration of several drugs and nitrite.药物与亚硝酸盐相互作用形成亚硝胺的研究。II. 几种药物与亚硝酸盐同时给药的肝毒性。
J Toxicol Sci. 1981 Nov;6(4):271-86. doi: 10.2131/jts.6.271.
6
Protective action of ascorbic acid against mutagenicity of aminopyrine plus nitrite.
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Ascorbic acid prevents liver tumour production by aminopyrine and nitrite in the rat.
Int J Cancer. 1977 Aug 15;20(2):268-70. doi: 10.1002/ijc.2910200215.
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Effect of ascorbic acid on the hepatotoxicity due to the daily intake of nitrate, nitrite and dimethylamine.
Nahrung. 1987;31(2):99-104. doi: 10.1002/food.19870310202.
9
[Effect of the administration of sodium nitrite and amidopyrine on the nucleic acid levels in the rat liver].
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Inhibitory effect of ascorbic acid on the acute toxicity of dimethylamine plus nitrite in the rat.
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引用本文的文献

1
Effects of antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone or ascorbic acid on carcinogenesis induced by administration of aminopyrine and sodium nitrite in a rat multi-organ carcinogenesis model.抗氧化剂1-O-己基-2,3,5-三甲基对苯二酚或抗坏血酸对大鼠多器官致癌模型中氨基比林和亚硝酸钠诱导的致癌作用的影响。
Jpn J Cancer Res. 2002 Dec;93(12):1299-307. doi: 10.1111/j.1349-7006.2002.tb01238.x.
2
[Ascorbic acid hinderance of the prenatal carcinogenic effect of ethylurea and nitrite].
Naturwissenschaften. 1973 Nov;60(11):525. doi: 10.1007/BF00603269.
3
Some EPR signals in tumour tissue.肿瘤组织中的一些电子顺磁共振信号。
Br J Cancer. 1973 Sep;28(3):257-62. doi: 10.1038/bjc.1973.145.
4
Kinetics of the nitrosation of aminopyrine to give dimethylnitrosamine.氨基比林亚硝化生成二甲基亚硝胺的动力学。
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974;82(4):259-68. doi: 10.1007/BF00285560.
5
Transaminase level (GOT, GPT) in rats under treatment with diethylnitrosamine.
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975;83(3):173-6. doi: 10.1007/BF00304084.
6
Carcinogenic N-nitro-dimethylamine from the reaction of the analgesic amidopyrine and nitrite extracted from foodstuffs.食品中提取的亚硝酸盐与止痛剂氨基比林反应生成致癌物质N-亚硝基二甲胺。
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975 Nov 25;84(3):299-10. doi: 10.1007/BF00312251.

本文引用的文献

1
Symposium on metabolism of inorganic compounds. II. Enzymatic pathways of nitrate, nitrite, and hydroxylamine metabolisms.无机化合物代谢研讨会。II. 硝酸盐、亚硝酸盐和羟胺代谢的酶促途径。
Bacteriol Rev. 1962 Mar;26(1):16-41. doi: 10.1128/br.26.1.16-41.1962.
2
Nitrosamines as environmental carcinogens.亚硝胺作为环境致癌物。
Nature. 1970 Jan 3;225(5227):21-3. doi: 10.1038/225021a0.
3
Ascorbate-nitrite reaction: possible means of blocking the formation of carcinogenic N-nitroso compounds.抗坏血酸盐-亚硝酸盐反应：阻断致癌性N-亚硝基化合物形成的可能方法。
Science. 1972 Jul 7;177(4043):65-8. doi: 10.1126/science.177.4043.65.
4
Nitrates, nitrites, and nitrosamines.
Science. 1972 Jul 7;177(4043):15-9. doi: 10.1126/science.177.4043.15.
5
Toxicity of nitrosamines: their possible human health hazards.亚硝胺的毒性：它们对人类健康可能造成的危害。
Food Cosmet Toxicol. 1971 Apr;9(2):207-18. doi: 10.1016/0015-6264(71)90306-3.
6
Carcinogenic nitroso compounds.致癌亚硝基化合物。
Adv Cancer Res. 1967;10:163-246. doi: 10.1016/s0065-230x(08)60079-2.
7
Carcinogen dimethylnitrosamine produced in vivo from nitrite and aminopyrine.
Nat New Biol. 1972 Apr 12;236(67):177-8. doi: 10.1038/newbio236177a0.
8
A nitrate reductase from Micrococcus denitrificans.一种来自反硝化微球菌的硝酸还原酶。
Biochim Biophys Acta. 1969 Apr 22;178(2):225-34. doi: 10.1016/0005-2744(69)90392-1.