Drenckhahn D, von Gaudecker B, Müller-Hermelink H K, Unsicker K, Gröschel-Stewart U
Virchows Arch B Cell Pathol Incl Mol Pathol. 1979 Dec;32(1):33-45. doi: 10.1007/BF02889011.
Samples of normal human thymus of different ages (4-63 years old) were studied by immunofluorescence microscopy (using antibodies to smooth muscle myosin, to actin from the chicken gizzard, and antibodies to myosin from human striated muscle) as well as by routine electron microscopy. Thymus tissue from myasthenia gravis patients was also investigated for comparative reasons. Epithelial cells reacted with anti-smooth, but not with anti-striated muscle myosin, whereas myoid cells reacted with antibodies to striated, but not to smooth muscle myosin. Both epithelial and myoid cells displayed a strong immunoreactivity with antiactin. Corresponding to this immunoreactivity, both cell types contained bundles of thin, actin-like filaments. Myoid cells occurred in the rounded and elongated variety, and they were a normal constituent of all thymuses investigated in this study. Ultrastructurally, this non-innervated, striated muscle-like cell type possessed bundles of thin and thick filaments as well as Z lines in a rather disorganized arrangement, resembling striated muscle after denervation or various other pathologic conditions. There were no overt differences in the number and structure of myoid cells between healthy and myasthenic patients.
利用免疫荧光显微镜技术（使用针对平滑肌肌球蛋白、鸡肫肌动蛋白以及人横纹肌肌球蛋白的抗体）以及常规电子显微镜技术，对不同年龄（4至63岁）的正常人胸腺样本进行了研究。出于比较的目的，还对重症肌无力患者的胸腺组织进行了调查。上皮细胞与抗平滑肌肌球蛋白抗体发生反应，但与抗横纹肌肌球蛋白抗体不发生反应，而肌样细胞与抗横纹肌肌球蛋白抗体发生反应，但与抗平滑肌肌球蛋白抗体不发生反应。上皮细胞和肌样细胞均与抗肌动蛋白抗体表现出强烈的免疫反应性。与这种免疫反应性相对应，两种细胞类型均含有成束的细肌动蛋白样细丝。肌样细胞有圆形和细长形两种形态，是本研究中所调查的所有胸腺的正常组成部分。在超微结构上，这种无神经支配的、类似横纹肌的细胞类型具有细肌丝和粗肌丝束以及Z线，其排列相当紊乱，类似于去神经支配后的横纹肌或其他各种病理状况下的横纹肌。健康患者和重症肌无力患者的肌样细胞在数量和结构上没有明显差异。
