Elleder M
Virchows Arch B Cell Pathol Incl Mol Pathol. 1979 Dec;32(1):89-92. doi: 10.1007/BF02889016.
Human splenic sinuses were observed for the induction of alkaline phosphatase (AP) activity in mucopolysaccharidoses of type I and II, in GM1 gangliosidosis, and in Niemann-Pick's disease, type A. A substantially lower degree of activity was found in Sanfillipo's disease, type A, and in hemosiderin pigmentation of the sinuses. In a number of hematological affections and in control spleens AP activity could not be proved by histochemical means. From the formal pathogenetic view, enzyme activity induction is probably related to lysosomal deposition of the material stored.
观察人类脾窦，以研究I型和II型黏多糖贮积症、GM1神经节苷脂贮积症和A型尼曼-匹克病中碱性磷酸酶（AP）活性的诱导情况。在A型桑菲利波病和脾窦含铁血黄素沉着症中发现活性程度明显较低。在一些血液学疾病和对照脾脏中，无法通过组织化学方法证实AP活性。从形式病理学观点来看，酶活性诱导可能与所储存物质的溶酶体沉积有关。
