Bryner J R, Greenblatt R B, Ellegood J O, Mahesh V B
South Med J. 1979 Jun;72(6):711-4. doi: 10.1097/00007611-197906000-00023.
Serum estrone, estradiol, progesterone, FSH, and LH levels were studied after the implantation of estradiol pellets in female volunteers in the reproductive age group. The estradiol pellets were implanted at six-month intervals. The first implant consisted of four pellets (25 mg each). Subsequent implants consisted of a reduction by one pellet as compared to the previous implant. The mean serum estradiol levels during the six-month period of implantation or at the end of six-month intervals were in the premenopausal range and did not differ significantly during the study. The serum estrone levels showed a tendency to increase with time even though the number of pellets implanted was decreasing, apparently a result of incomplete absorption of the implanted estradiol during the six-month period. The results of serum progesterone determinations and basal body temperature records indicate that the suppression of ovulation takes place most consistently during the second and subsequent months after estradiol pellet implantation.
对育龄期女性志愿者植入雌二醇丸剂后，研究了其血清雌酮、雌二醇、孕酮、促卵泡激素（FSH）和促黄体生成素（LH）水平。雌二醇丸剂每隔六个月植入一次。首次植入由四个丸剂（每个25毫克）组成。后续植入的丸剂数量比前一次植入减少一个。植入六个月期间或六个月间隔结束时的平均血清雌二醇水平处于绝经前范围，且在研究期间无显著差异。血清雌酮水平显示出随时间增加的趋势，尽管植入的丸剂数量在减少，这显然是六个月期间植入的雌二醇吸收不完全的结果。血清孕酮测定结果和基础体温记录表明，雌二醇丸剂植入后的第二个月及后续月份，排卵抑制最为持续。
