肌红蛋白活性位点的合成。
Synthesis of the myoglobin active site.
作者信息
Chang C K, Traylor T G
出版信息
Proc Natl Acad Sci U S A. 1973 Sep;70(9):2647-50. doi: 10.1073/pnas.70.9.2647.
Abstract
A simple heme-imidazole compound, having the same geometry as the heme-imidazole complex in myoglobin, has been synthesized. This compound, ferropyrroporphyrin-N-[3-(1-imidazolyl)propyl]amide, reversibly binds oxygen in the solid state or when dissolved in a polystyrene film. These results suggest that the principal factors governing reversible oxygen binding are the electronic nature of the base (imidazole), neighboring-group effects of the basic group, and immobilization of the heme group.
摘要
一种具有与肌红蛋白中血红素 - 咪唑复合物相同几何结构的简单血红素 - 咪唑化合物已被合成。该化合物，即铁卟啉 - N - [3 - (1 - 咪唑基)丙基]酰胺，在固态或溶解于聚苯乙烯薄膜中时能可逆地结合氧气。这些结果表明，控制可逆氧结合的主要因素是碱（咪唑）的电子性质、碱性基团的邻位基团效应以及血红素基团的固定化。
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