Maruhama Y, Abe R, Okuguchi F, Ohneda A, Goto Y
Tohoku J Exp Med. 1979 May;128(1):19-29. doi: 10.1620/tjem.128.19.
Fifty relatives of 7 families with high prevalence of obesity were investigated and the possibility was shown that there were three forms of familial obesity--normoinsulinemic obesity, hyperinsulinemic obesity and diabetic obesity. In normoinsulinemic obesity, both glucose tolerance and plasma lipids were normal with a few exceptions whereas in hyperinsulinemic obesity, mild glucose intolerance and manifest hyperlipidemia, and in diabetic obesity, blunted insulinogenic index and more advanced glucose intolerance with slight hyperlipidemia existed.
对7个肥胖高发家族的50名亲属进行了调查，结果表明存在三种家族性肥胖形式——正常胰岛素血症性肥胖、高胰岛素血症性肥胖和糖尿病性肥胖。在正常胰岛素血症性肥胖中，除少数例外，葡萄糖耐量和血脂均正常；而在高胰岛素血症性肥胖中，存在轻度葡萄糖不耐受和明显的高脂血症；在糖尿病性肥胖中，则存在胰岛素生成指数降低、更严重的葡萄糖不耐受以及轻度高脂血症。
