新型血清素代谢产物5-羟犬尿胺对离体犬基底动脉的影响。

Effects of 5-hydroxykynurenamine, a new serotonin metabolite, on isolated dog basilar arteries.

作者信息

Toda N, Tokuyama T, Seno S, Hirata F, Hayaishi O

出版信息

Proc Natl Acad Sci U S A. 1974 Jan;71(1):122-4. doi: 10.1073/pnas.71.1.122.

DOI:10.1073/pnas.71.1.122

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC387947/

Abstract

Serotonin and 5-hydroxykynurenamine caused dose-related contractions in the spiral strips of dog basilar arteries. The potency of 5-hydroxykynurenamine was approximately 1/100 that of serotonin, the former frequently causing a transient relaxation preceding the contraction. The contractile responses to 5-hydroxykynurenamine and serotonin were attenuated by methysergide. Treatment with 5-hydroxykynurenamine inhibited the response to serotonin, and this inhibitory effect was not completely reversed by removal of 5-hydroxykynurenamine from the bathing medium. The contractile response to K(+) was only slightly attenuated by high concentrations of 5-hydroxykynurenamine. It appears that 5-hydroxykynurenamine and serotonin share receptors in dog basilar arteries and that the effect of serotonin is specifically antagonized by 5-hydroxykynurenamine.

摘要

血清素和5-羟基犬尿胺可使犬基底动脉螺旋条产生剂量相关的收缩。5-羟基犬尿胺的效力约为血清素的1/100，前者在收缩前常引起短暂的舒张。5-羟基犬尿胺和血清素的收缩反应可被美西麦角减弱。用5-羟基犬尿胺处理可抑制对血清素的反应，且这种抑制作用不会因从浴液中去除5-羟基犬尿胺而完全逆转。高浓度的5-羟基犬尿胺仅轻微减弱对钾离子（K(+)）的收缩反应。看来5-羟基犬尿胺和血清素在犬基底动脉中共享受体，且血清素的作用可被5-羟基犬尿胺特异性拮抗。

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