抗体介导的淋巴瘤抑制作用：血小板、淋巴细胞和非吞噬性巨噬细胞的参与
Antibody-mediated suppression of lymphoma: participation of platelets, lymphocytes, and nonphagocytic macrophages.
作者信息
Shin H S, Hayden M L, Gately C L
出版信息
Proc Natl Acad Sci U S A. 1974 Jan;71(1):163-6. doi: 10.1073/pnas.71.1.163.
Abstract
Humoral antibody directed against a grafted murine lymphoma can suppress the growth of the tumor in mice of the inbred strain native to the tumor. Antibody, however, cannot suppress the tumor growth in mice given 500 R of whole-body irradiation. When the tumor-antibody inoculum is admixed with lymphocytes or macrophages obtained from peritoneal exudate, macrophages experimentally rendered nonphagocytic, or with platelets isolated from peripheral blood, the tumor growth is suppressed in irradiated mice. These results indicate that mechanisms other than phagocytosis may play an important role in antibody-mediated suppression of tumor growth in vivo.
摘要
针对移植的小鼠淋巴瘤的体液抗体能够抑制该肿瘤在其原本所属近交系小鼠体内的生长。然而，抗体无法抑制接受500拉德全身照射的小鼠体内肿瘤的生长。当肿瘤-抗体接种物与从腹腔渗出液中获取的淋巴细胞或巨噬细胞、经实验处理使其失去吞噬能力的巨噬细胞，或从外周血中分离出的血小板混合时，照射后的小鼠体内肿瘤生长受到抑制。这些结果表明，除吞噬作用外的其他机制可能在抗体介导的体内肿瘤生长抑制中发挥重要作用。
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Antibody-mediated suppression of lymphoma: participation of platelets, lymphocytes, and nonphagocytic macrophages.抗体介导的淋巴瘤抑制作用：血小板、淋巴细胞和非吞噬性巨噬细胞的参与
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本文引用的文献
1
Opsonization of cells by isoantibody in vitro.体外同种抗体对细胞的调理作用。
Nature. 1963 Apr 6;198:10-2. doi: 10.1038/198010a0.
2
3
Complete in vivo destruction of allografted sarcoma I cells by circulating antibodies.循环抗体对同种异体移植肉瘤I细胞的完全体内破坏。
Transplantation. 1970 Nov;10(5):450-1. doi: 10.1097/00007890-197011000-00020.
4
Absorption of guinea pig serum with agar. A method for elimination of itscytotoxicity for murine thymus cells.用琼脂吸收豚鼠血清。一种消除其对小鼠胸腺细胞细胞毒性的方法。
Transplantation. 1970 Jul;10(1):130-2. doi: 10.1097/00007890-197007000-00027.
5
Cytotoxic lymphocytes from rats depleted of thymus processed cells.来自胸腺处理细胞耗竭的大鼠的细胞毒性淋巴细胞。
Nat New Biol. 1971 Jul 21;232(29):80-2. doi: 10.1038/newbio232080a0.
6
Antibody-mediated suppression of grafted lymphoma cells. I. Participation of a host factor(s) other than complement.抗体介导的移植淋巴瘤细胞抑制作用。I. 补体以外宿主因子的参与
Proc Soc Exp Biol Med. 1972 Feb;139(2):684-9. doi: 10.3181/00379727-139-36216.
7
Antibody-mediated suppression of grafted lymphoma cells. II. Participation of macrophages.抗体介导的移植淋巴瘤细胞抑制作用。II. 巨噬细胞的参与
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Science. 1972 Jan 14;175(4018):194-6. doi: 10.1126/science.175.4018.194.
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