Shin H S, Hayden M L, Gately C L
Proc Natl Acad Sci U S A. 1974 Jan;71(1):163-6. doi: 10.1073/pnas.71.1.163.
Humoral antibody directed against a grafted murine lymphoma can suppress the growth of the tumor in mice of the inbred strain native to the tumor. Antibody, however, cannot suppress the tumor growth in mice given 500 R of whole-body irradiation. When the tumor-antibody inoculum is admixed with lymphocytes or macrophages obtained from peritoneal exudate, macrophages experimentally rendered nonphagocytic, or with platelets isolated from peripheral blood, the tumor growth is suppressed in irradiated mice. These results indicate that mechanisms other than phagocytosis may play an important role in antibody-mediated suppression of tumor growth in vivo.
针对移植的小鼠淋巴瘤的体液抗体能够抑制该肿瘤在其原本所属近交系小鼠体内的生长。然而,抗体无法抑制接受500拉德全身照射的小鼠体内肿瘤的生长。当肿瘤-抗体接种物与从腹腔渗出液中获取的淋巴细胞或巨噬细胞、经实验处理使其失去吞噬能力的巨噬细胞,或从外周血中分离出的血小板混合时,照射后的小鼠体内肿瘤生长受到抑制。这些结果表明,除吞噬作用外的其他机制可能在抗体介导的体内肿瘤生长抑制中发挥重要作用。