Shin H S, Kaliss N, Borenstein D, Gately M K
J Exp Med. 1972 Aug 1;136(2):375-80. doi: 10.1084/jem.136.2.375.
Specific alloantibody admixed with a grafted murine lymphoma is suppressive of the graft in mice of the inbred strain native to the tumor. Suppressive capacity of the host is obviated in mice given 500 R whole body irradiation before tumor inoculation but is restored when normal peritoneal macrophages are admixed with the tumor-antibody inoculum. Other normal cell types admixed with the tumor-antibody inoculum are not effective in restoring suppressive capacity.
与移植的小鼠淋巴瘤混合的特异性同种异体抗体可抑制肿瘤原近交系小鼠体内的移植物。在肿瘤接种前接受500拉德全身照射的小鼠中,宿主的抑制能力消失,但当正常腹膜巨噬细胞与肿瘤-抗体接种物混合时,抑制能力得以恢复。与肿瘤-抗体接种物混合的其他正常细胞类型在恢复抑制能力方面无效。