变性：一种灾变的例子。
Denaturation: an example of a catastrophe.
作者信息
Kozak J J, Benham C J
出版信息
Proc Natl Acad Sci U S A. 1974 May;71(5):1977-81. doi: 10.1073/pnas.71.5.1977.
We show that a "phase diagram" for the conformational states of proteins can be constructed using the mathematical theory of singularities of functions developed recently by René Thom. For proteins subjected to the disruptive influences of temperature and/or concentration of denaturing agent, this theory can be used as a predictive tool to account for the shape, sense, and changes in the curves that result when the optical rotatory dispersion is plotted as a function of these two constraints. The mathematical model is found to be in accord with known experimental data on collagen, lysozyme, and ribonuclease.
我们表明，可以利用勒内·托姆最近提出的函数奇点数学理论构建蛋白质构象状态的“相图”。对于受到温度和/或变性剂浓度破坏影响的蛋白质，该理论可作为一种预测工具，用于解释将旋光色散作为这两个制约因素的函数绘制时所得曲线的形状、走向和变化。发现该数学模型与关于胶原蛋白、溶菌酶和核糖核酸酶的已知实验数据相符。
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