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Prolongation of the life-span in mice adapted to large amounts of L-dopa.

作者信息

Cotzias G C, Miller S T, Nicholson A R, Maston W H, Tang L C

出版信息

Proc Natl Acad Sci U S A. 1974 Jun;71(6):2466-9. doi: 10.1073/pnas.71.6.2466.

DOI:10.1073/pnas.71.6.2466
PMID:4526220
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC388479/
Abstract

Various concentrations of L-dopa (levodopa, L-3,4-dihydroxyphenylalanine) were incorporated in the diets of young male Swiss albino mice, and the highest concentrations to which these mice became adapted within 3 weeks were determined. One such concentration administered indefinitely eventually induced a youthful appearance, a significantly prolonged life-span, but also corneal opacities compatible with traumatic or chemical keratitis.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60b5/388479/13f1fa5f9a99/pnas00059-0318-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60b5/388479/13f1fa5f9a99/pnas00059-0318-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60b5/388479/13f1fa5f9a99/pnas00059-0318-a.jpg

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本文引用的文献

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Increased plasma bilirubin in Parkinson patients on L-dopa: evidence against the free radical hypothesis?帕金森病患者服用左旋多巴后血浆胆红素升高:是否有证据反驳自由基假说?
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An investigation of a new instrument to measure motor activity of small animals.
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