β受体阻滞剂在甲状腺功能亢进症中的作用。
Effect of beta-blocking agents in hyperthyroidism.
作者信息
Földes J, Bános C, Borvendég J, Gyertyánfy G
出版信息
Acta Med Acad Sci Hung. 1979;36(4):375-80.
PMID:45285
Abstract
Propranolol modifies peripheral thyroxine metabolism, in opposition to the beta blocking agent GYKI 41099 which has no such effect. Both beta-receptor blockers produce a significant fall in the serum cAMP level of hyperthyroid subjects. It is suggested that the beneficial effect of the beta-blocking agents in hyperthyroidism is partly due to their depressive effect on cAMP production. As far as the action of propranolol is concerned, it may well involve an additional effect on T4 metabolism.
摘要
普萘洛尔可改变外周甲状腺素代谢，这与β受体阻滞剂GYKI 41099不同，后者无此作用。两种β受体阻滞剂均可使甲状腺功能亢进患者的血清环磷酸腺苷（cAMP）水平显著下降。提示β受体阻滞剂对甲状腺功能亢进有益的作用部分归因于其对cAMP产生的抑制作用。就普萘洛尔的作用而言，它很可能还对T4代谢有额外作用。
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